MP58-05 ENDOSCOPIC AND HISTOLOGIC FINDINGS IN A COHORT OF APATITE, BRUSHITE AND CALCIUM OXALATE STONE FORMERS

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Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming rats.

Over 59 generations, a strain of rats has been inbred to maximize urine calcium excretion. The rats now excrete eight to 10 times as much calcium as controls. These rats uniformly form calcium phosphate (apatite) kidney stones and have been termed genetic hypercalciuric stone-forming (GHS) rats. The addition of a common amino acid and oxalate precursor, hydroxyproline, to the diet of the GHS ra...

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ژورنال

عنوان ژورنال: Journal of Urology

سال: 2016

ISSN: 0022-5347,1527-3792

DOI: 10.1016/j.juro.2016.02.803